Type: DNA FRAGMENTATION ANALYSIS, HUMAN DIAGNOSTIC
Dynhalosperm® has been developed in response to the users´needs to assess the kinetic aspects of sperm DNA damage.
Interest in this aspect is growing because the use of sperm samples ex vivo may produce iatrogenic sperm damage which appears to be quite different among individuals. It´s been demonstrated that sperm DNA fragmentation is present from the first moment of ejaculation and damage increases over time. DNA longevity is different among different patients. Patients presenting a High Rate of sperm DNA damage after ejaculation needs to be identified to avoid extra iatrogenic sperm damage.
As such Dynhalosperm® allows clinicians to add more information in their decision making process about which assisted reproductive treatment would suit best for a given couple. For example, a patient presenting a high rate of sperm DNA fragmentation would be recommended to use an ART strategy that ensures short periods of in vitro manipulation and a rapid fertilization of the oocyte.
Dynhalosperm® is useful for selecting the optimum moment to carry out an ART cycle, for assessing the quality of semen samples and for providing answers to cases of unexplained infertility and repeated abortions.
The green line describes a patient with low basal SDF but with a high rate of sperm DNA fragmentation. The pink line describes a patient with higher basal level of DNA damage but with a low rate of sperm DNA fragmentation. In the first case, the insemination or the sperm selection for ART must be immediately performed to avoid iatrogenic DNA damage. The incidence of iatrogenic DNA damage in the second patient is not so intense
ENGLISH
